Pyridoxal 5'-phosphate (CSF)


Test Details
TEST CODE NC05
TEST METHODOLOGY HPLC/Fluorescence
TAT (TURNAROUND TIME) 10 - 14 days
CPT CODE 82542
PRICE $190
RECOMMENDED MNG KITS
  • CSF Collection Tubes (set of 5 tubes per kit)

Order Kit


Clinical Information
Clinical Significance CSF Pyridoxal 5'-phosphate (NC05) is useful for diagnosis of disorders leading to low CSF levels of this cofactor. This testing may also be used for assessment of Variants of Uncertain Significance (VUS) identified during genetic testing (e.g. Next Generation Sequencing or Capillary Sequencing Testing). CLINICAL Pryridoxal 5'phosphate (PLP) (a memeber of the vitamin B6 family) is required as a cofactor for over 100 different enzymes in the body. These may involve the metabolism of various neurotransmitters and amino acids. Inadequate PLP may occur due to genetic, nutritional deficiencies as well as reaction with various drugs. Inherited disorders that affect the CSF PLP level include pyridox(am)ine phosphate oxidase (PNPO) deficiency, alpha aminoadipic semialdehyde dehydrogenase deficiency, hyperprolinermia type 2 and hypophoshatasia due to alkaline phosphatase deficiency.
Relevant Diseases
  • Pyridoxamine 5-Prime-Phosphate Oxidase Deficiency

Specimen Information
Acceptable Sample Types
  • Cerebrospinal Fluid (CSF)
Sample Preparation: Fill the tubes sequentially to the marked line Tube 1: 0.5 milliliter, Tube 2: 1.0 milliliter, Tube 3: 1.0 milliliter, Tube 4: 1.0 milliliter, Tube 5: 1.0 milliliter Without MNG CSF Collection Kit: Collect samples into 5 numbered 2.0 mL microcentrifuge tubes (or similar): Tube 1: 0.5 milliliter, Tube 2: 1.0 milliliter, Tube 3: 1.0 milliliter, Tube 4: 1.0 milliliter, Tube 5: 1.0 milliliter OR Collect entire sample into a single sterile tube, which is considered a pooled CSF sample. Neurotransmitter analysis may only be informative for certain disorders (NC04 analysis). Please contact the laboratory for more information.
Shipping Condition: Ship samples priority overnight on 3-4 lbs of dry ice. Sample must arrive in our lab Monday - Saturday. We do NOT accept Sunday or holiday deliveries.


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