Folate Receptor Antibody Assay (Plasma/Serum)

Test Details
TAT (TURNAROUND TIME) 10 - 14 days
CPT CODE 83520
PRICE $250

Clinical Information
Clinical Significance
Folate receptor antibody assay (MET22) is useful for investigating the cause of a cerebral folate deficiency. CLINICAL Folate supplementation reduces the risk of neural tube defect (NTD) pregnancy, and folinic acid has been used to correct cerebral folate deficiency (CFD) in children with developmental disorders. In the absence of systemic folate deficiency, the discovery of autoantibodies (AuAbs) to folate receptor ? (FR?) that block the uptake of folate offers one mechanism to explain the response to folate in these disorders. The association of FR? AuAbs with pregnancy-related complications, CFD syndrome, and autism spectrum disorders and response to folate therapy is highly suggestive of the involvement of these AuAbs in the disruption of brain development and function via folate pathways.
Relevant Diseases
  • Neurodegeneration due to Cerebral Folate Transport Deficiency

Specimen Information
Acceptable Sample Types
  • Plasma
  • Serum
Sample Preparation: Serum or plasma: Collect 2-4 milliliters of blood in serum tube (red top) or sodium heparin tube (green top). Remove serum or plasma and freeze at -20°Celsius. Store frozen at –20°Celsius and ship frozen. Preferred volume: 0.25 milliliter, minimum volume: 0.1 milliliter
Shipping Condition: Ship samples priority overnight on 3-4 lbs of dry ice. Sample must arrive in our lab Monday - Saturday. We do NOT accept Sunday or holiday deliveries.

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