About Other Inherited Disorders
MNG is well known for our expertise in diagnosing the most complex neurogenetic challenges. In addition to our core disease categories, we proudly offer next-generation sequencing (NGS) with copy number analysis in other areas of neurology, where clinical presentation may impact multiple organ systems. These include: neurosensory, neurovascular, neurocutaneous, and nephrology conditions. The expansion of our portfolio highlights our unique approach and deep understanding of medical diagnoses through offering a comprehensive menu of genetic tests.
Other Inherited Disorders Tests We Offer
Neurosensory disorders include a variety of conditions affecting the five major senses, with a focus on vision and hearing disorders. Our Stickler Syndrome and Usher Syndrome panels cover the major types of these syndromes. MNG also includes a Pain Syndrome panel in this category, which includes genes covering several phenotypes of hereditary neurological pain.
Neurovascular disorders affect the complex relationship between nerves and blood vessels, including aneurysms, strokes, and subarachnoid hemorrhages. At MNG Laboratories, our expertise in both neurological and cardiovascular disease naturally results in the expansion of our test offerings to include more specific neurovascular conditions, such as Stroke, Ehlers Danlos and Aneurysm Syndromes, and Familial Hemiplegic Migraine.
Neurocutaneous disorders involve the nervous tissue and its intricate relationship with surrounding organs. MNG’s diagnostic panels for Neurofibromatosis and Tuberous Sclerosis are important additions to our testing portfolio. With the autosomal dominant inheritance pattern, wide variety of symptomatology, and subsequent tumor growth for both disorders, a genetic diagnosis is essential for the patient’s treatment plan.
MNG includes major nephrology disorder testing in our diagnostic portfolio, as the clinical symptoms impact both the muscle and nervous systems. Disorders such as Polycystic Kidney Disease and Bartter/Gitelman Syndrome can present with muscle weakness and spasms due to the kidneys’ inability to properly filter salt ions. Conversely, other neurological conditions can affect proper kidney function.
Whole Exome Sequencing for Comprehensive Diagnostics
For disorders that fall outside of our extensive panel offerings, we provide whole exome sequencing with our MNG Exome™. This comprehensive diagnostic tool features sequencing of all protein-coding exons in the human genome with copy number analysis and complimentary mitochondrial genome sequencing with deletion analysis.
MNG Laboratories is committed to a patient-centered testing menu, high-quality diagnostics, and first-in-class reporting driven by our Genome MaNaGer® analysis pipeline. Our Neurogenetic Answers™ reporting process helps us stay at the forefront of the evolving genetics field with our regularly-updated NGS panels. Our team-based approach to variant calls ensures we provide actionable results on the pathogenic variants that cause or are likely to cause disease. Our comprehensive approach to diagnostics is accompanied by a team of customer support and scientific personnel available to answer your questions regarding our process, technology, and reports. Please contact us to learn more about how we may serve you and your patients.