MNG VIP™ – Variant Investigation Program
For next-generation sequencing (NGS) panels and single gene testing performed at MNG Labs, there are many cases where parental or immediate family member testing would be helpful for variant/VUS interpretation or identifying de novo variants in a proband. Through the MNG Variant Investigation Program (VIP), testing for parents or immediate family members will be at no cost in qualifying variants, effective for samples received after October 15, 2018.
MNG VIP™ is only applicable to NGS panel and single gene reports with qualifying variants indicated. Reports with these variants will have text noting whether they qualify for no cost familial testing through this program. Up to two immediate (parent/sibling) family members can be submitted for free familial testing through MNG VIP, with no limit on the number of qualifying variants.
With the MNG VIP™, an updated report will be issued for the proband, in an effort to reclassify the variants in question. Family members will not receive a report through this program.
To get started, please review the program details below, and then go to our Forms page to find the Familial Variant Test Request Form. This form must accompany all samples submitted for no cost testing. Testing will not begin until all familial samples have been received, and the standard TAT is 2-4 weeks from approval of submitted cases (please allow up to one week for processing and qualification).
Which variants are eligible for the MNG VIP™?
- Variants of uncertain significance (VUS) detected in a gene that causes disorders with dominant inheritance.
- Two variants (VUS or Pathogenic/Likely Pathogenic) were detected in a gene that causes disorders with recessive inheritance and phase (CIS vs TRANS) could not be determined from the sequencing data.