MNG VIP – Variant Investigation Program

For next-generation sequencing (NGS) panels and single gene testing performed at MNG Labs, there are many cases where parental or immediate family member testing would be helpful for variant/VUS interpretation or identifying de novo variants in a proband. Through the MNG Variant Investigation Program (VIP), testing for parents or immediate family members will be at no cost in qualifying variants, effective for samples received after October 15, 2018.

MNG VIP™ is only applicable to NGS panel and single gene reports with qualifying variants indicated. Reports with these variants will have text noting whether they qualify for no cost familial testing through this program. Up to two immediate (parent/sibling) family members can be submitted for free familial testing through MNG VIP, with no limit on the number of qualifying variants.

With the MNG VIP™, an updated report will be issued for the proband, in an effort to reclassify the variants in question. Family members will not receive a report through this program.

To get started, please review the program details below, and then go to our Forms page to find the Familial Variant Test Request Form. This form must accompany all samples submitted for no cost testing. Testing will not begin until all familial samples have been received, and the standard TAT is 2-4 weeks from approval of submitted cases (please allow up to one week for processing and qualification).


Which variants are eligible for the MNG VIP™?

  • Variants of uncertain significance (VUS) detected in a gene that causes disorders with dominant inheritance.
  • Two variants (VUS or Pathogenic/Likely Pathogenic) were detected in a gene that causes disorders with recessive inheritance and phase (CIS vs TRANS) could not be determined from the sequencing data.
Notation will be made on the proband report for qualifying variants, including both single nucleotide variants (SNV) and copy number variants (CNV). Variants from mitochondrial DNA analysis are also eligible if noted; in such cases, only a maternal sample will need to be provided.

Which family members are included for testing?

Parental samples are encouraged, but MNG understands that in some cases both parents may not be available. We will only accept immediate familial samples that will be able to help in classifying the variant in the proband. Please feel free to contact us to help determine if family members will be accepted for those cases in which both parents are not available.

Will family members receive a report?

Family members tested through MNG VIP™ will not receive an individual variant report. Only the proband will receive an updated report, even if there is no change to the classification of the variant. If those family members tested through the MNG VIP™ would like to receive a report, they will need to order standard known familial variant testing at list price.

What MNG testing does the MNG VIP™ apply to?

The MNG VIP™ only applies to next-generation sequencing (NGS) panels and single gene analysis performed at MNG Labs. Whole exome sequencing is not included in this program.

Additional Family Member Testing

Additional or non-informative family members can be tested through standard Known Familial Variant testing. This includes SNV and CNV variants. Separate reports will be generated for each family member submitted.

External Samples

Familial testing for proband samples not performed at MNG are limited to SNV variants only and can be submitted through our Known Familial Variant testing. Separate reports will be generated for each patient submitted.